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4-Nitrophenyl α-D-galactopyranoside

CAS No. 7493-95-0

4-Nitrophenyl α-D-galactopyranoside ( PNP-alpha-D-Gal; PNP-α-D-Gal )

Catalog No. M27057 CAS No. 7493-95-0

4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-Nitrophenyl α-D-galactopyranoside
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity.
  • Description
    4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates.(In Vitro):Using 4-nitrophenol (pNP)-glycopyranosides as pseudosubstrates, the amount of liberated pNP from the 4-Nitrophenyl α-D-galactopyranoside is significantly higher than that from the other pNP-glycopyranosides at pH 4.0 whereas no activity was detected at pH 7.0. The digestion assays using pNP glycopyranosides as artificial substrates show that yielding liberated galactose residues from 4-Nitrophenyl α-D-galactopyranoside mainly at pH 4.0, i.e. the pH level where yield threshold is decreased at most.
  • Synonyms
    PNP-alpha-D-Gal; PNP-α-D-Gal
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Alkyl-Chain; Non-cleavable
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7493-95-0
  • Formula Weight
    301.3
  • Molecular Formula
    C12H15NO8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@@H]1[C@H](O)[C@@H](O)[C@@H](OC2=CC=C([N+]([O-])=O)C=C2)O[C@@H]1CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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